Pseudomonas aeruginosa PAO1 adapted to 2-phenoxyethanol shows cross-resistance to dissimilar biocides and increased susceptibility to antibiotics
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antibakteriální látky farmakologie MeSH
- biologická adaptace MeSH
- dezinficiencia metabolismus toxicita MeSH
- elektroforéza v polyakrylamidovém gelu MeSH
- ethylenglykoly metabolismus toxicita MeSH
- mikrobiální testy citlivosti MeSH
- proteiny vnější bakteriální membrány analýza MeSH
- proteom analýza MeSH
- Pseudomonas aeruginosa fyziologie MeSH
- sériové pasážování MeSH
- tolerance léku * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- dezinficiencia MeSH
- ethylenglykoly MeSH
- phenoxyethanol MeSH Prohlížeč
- proteiny vnější bakteriální membrány MeSH
- proteom MeSH
The growth adaptability to increasing concentration of the biocide 2-phenoxyethanol (PE) was determined in Pseudomonas aeruginosa PAO1 (P.a.) as part of efforts to understand and control the biocide tolerance and its effect on cross-resistance to other biocides and resistance to antibiotics. After repeated subculturing in media containing increasing sub-minimum-inhibitory PE concentration, P.a. exhibited an adaptive resistance indicated by two-fold increase in MIC at the 10th passage. The resistance was stable and remained after passaging the strain in further 7 successive passages in PE-free growth media. The strain showed cross-resistance towards dissimilar biocides and displayed increased susceptibility to antibiotics, which was not influenced by the presence of the efflux inhibitor 'carbonyl cyanide m-chlorophenyl hydrazone'. Outer membranes of adapted strain showed altered protein profile when examined by SDS-PAGE.
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