Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib
Language English Country Japan Media print
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21422703
DOI
10.3177/jnsv.56.347
PII: JST.JSTAGE/jnsv/56.347
Knihovny.cz E-resources
- MeSH
- alpha-Tocopherol blood MeSH
- Benzamides MeSH
- Adult MeSH
- Gastrointestinal Stromal Tumors blood drug therapy metabolism MeSH
- Imatinib Mesylate MeSH
- Intestinal Absorption drug effects MeSH
- Dietary Sucrose pharmacokinetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Permeability MeSH
- Piperazines pharmacology therapeutic use MeSH
- Antineoplastic Agents pharmacology therapeutic use MeSH
- Pyrimidines pharmacology therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Intestinal Mucosa drug effects metabolism MeSH
- Vitamin A pharmacokinetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- alpha-Tocopherol MeSH
- Benzamides MeSH
- Imatinib Mesylate MeSH
- Dietary Sucrose MeSH
- Piperazines MeSH
- Antineoplastic Agents MeSH
- Pyrimidines MeSH
- Vitamin A MeSH
Administration of imatinib is the therapy of choice in patients with advanced (inoperable) or metastatic gastrointestinal stromal tumors (GIST). Gastrointestinal toxicity is one of the most common side effects of anticancer therapy, including imatinib. Measurement of intestinal permeability represents a method of noninvasive laboratory assessment of gastrointestinal toxicity. We have measured intestinal permeability (by determining absorption of lactulose, mannitol and xylose), vitamin A absorption and serum alpha-tocopherol in 16 patients with advanced/metastatic GIST treated with imatinib. Lactulose/mannitol and lactulose/xylose ratios as well as parameters of vitamin A absorption did not change significantly during the treatment, but a significant decrease of alpha-tocopherol was observed. We conclude that, in contrast to most other anticancer agents studied so far, imatinib does not have an effect on intestinal permeability. No effect on vitamin A absorption was observed, but serum alpha-tocopherol decreased significantly during the treatment.
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