Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- Alicyclobacillus metabolismus MeSH
- antibakteriální látky biosyntéza MeSH
- butyráty metabolismus MeSH
- ivermektin analogy a deriváty metabolismus MeSH
- kyseliny pentanové metabolismus MeSH
- mastné kyseliny biosyntéza MeSH
- Rhodococcus metabolismus MeSH
- Streptomyces metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 2-methylbutanoic acid MeSH Prohlížeč
- antibakteriální látky MeSH
- avermectin MeSH Prohlížeč
- butyráty MeSH
- ivermektin MeSH
- kyseliny pentanové MeSH
- mastné kyseliny MeSH
- pivalic acid MeSH Prohlížeč
A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin.
Citace poskytuje Crossref.org
