Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Alicyclobacillus metabolism MeSH
- Anti-Bacterial Agents biosynthesis MeSH
- Butyrates metabolism MeSH
- Ivermectin analogs & derivatives metabolism MeSH
- Pentanoic Acids metabolism MeSH
- Fatty Acids biosynthesis MeSH
- Rhodococcus metabolism MeSH
- Streptomyces metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2-methylbutanoic acid MeSH Browser
- Anti-Bacterial Agents MeSH
- avermectin MeSH Browser
- Butyrates MeSH
- Ivermectin MeSH
- Pentanoic Acids MeSH
- Fatty Acids MeSH
- pivalic acid MeSH Browser
A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin.
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