The role of the inferior frontal gyri in cognitive processing of patients with Parkinson's disease: a pilot rTMS study
Language English Country United States Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
21480374
DOI
10.1002/mds.23663
Knihovny.cz E-resources
- MeSH
- Frontal Lobe physiology MeSH
- Double-Blind Method MeSH
- Inhibition, Psychological MeSH
- Cross-Over Studies MeSH
- Cognition Disorders etiology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Parkinson Disease complications MeSH
- Pilot Projects MeSH
- Aged MeSH
- Vocabulary MeSH
- Transcranial Magnetic Stimulation * MeSH
- Color Perception MeSH
- Mental Status Schedule MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
BACKGROUND: We studied whether 1 session of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied sequentially over both the left and right inferior frontal gyri (IFG) would enhance performance in tests evaluating the ability to inhibit habitual responses (Stroop test, ST; Frontal Assessment Battery, FAB) in patients with Parkinson's disease (PD). METHODS: Ten nondemented PD patients (6 men, 4 women; age, 66 ± 6 years; disease duration, 5.4 ± 2.45 years) entered the randomized, sham stimulation-controlled study with a crossover design. The ST and the FAB were performed prior to and immediately after an appropriate rTMS session. RESULTS: The active but not sham rTMS induced significant improvement in all ST subtests (word, color, color-word). Conversely, the calculated Stroop interference and the FAB scores remained unchanged. CONCLUSIONS: In PD patients, rTMS of the IFG increased the speed of cognitive processing in both the congruent and incongruent conditions of the ST.
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