Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21842058
DOI
10.1039/c1dt10674k
Knihovny.cz E-zdroje
- MeSH
- 2,2'-dipyridyl analogy a deriváty chemie farmakologie MeSH
- 4-chinolony chemie farmakologie MeSH
- antitumorózní látky chemie farmakologie MeSH
- DNA metabolismus MeSH
- fenantroliny chemie farmakologie MeSH
- krystalografie rentgenová MeSH
- lidé MeSH
- měď chemie farmakologie MeSH
- molekulární modely MeSH
- nádorové buněčné linie MeSH
- nádory farmakoterapie MeSH
- organokovové sloučeniny chemie farmakologie MeSH
- skot MeSH
- štěpení DNA účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 1,10-phenanthroline MeSH Prohlížeč
- 2,2'-dipyridyl MeSH
- 2,2'-dipyridylamine MeSH Prohlížeč
- 4-chinolony MeSH
- 5-methyl-1,10-phenanthroline MeSH Prohlížeč
- 5-nitro-1,10-phenanthroline MeSH Prohlížeč
- antitumorózní látky MeSH
- bathophenanthroline MeSH Prohlížeč
- calf thymus DNA MeSH Prohlížeč
- DNA MeSH
- fenantroliny MeSH
- měď MeSH
- organokovové sloučeniny MeSH
A series of mixed-ligand complexes [Cu(qui)(L)]NO(3)·xH(2)O (1-6), where Hqui = 2-phenyl-3-hydroxy-4(1H)-quinolinone, L = 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), bis(2-pyridyl)amine (ambpy) (3), 5-methyl-1,10-phenanthroline (mphen) (4), 5-nitro-1,10-phenanthroline (nphen) (5) and bathophenanthroline (bphen) (6), have been synthesized and fully characterized. The X-ray structures of [Cu(qui)(phen)]NO(3)·H(2)O (2) and [Cu(qui)(ambpy)]NO(3) (3a) show a slightly distorted square-planar geometry in the vicinity of the central copper(II) atom. An in vitro cytotoxicity study of the complexes found significant activity against human osteosarcoma (HOS) and human breast adenocarcinoma (MCF7) cell lines, with the best results for complex 6, where IC(50) equals to 2.1 ± 0.2 μM, and 2.2 ± 0.4 μM, respectively. The strong interactions of the complexes with calf thymus DNA (CT-DNA) and high ability to cleave pUC19 DNA plasmid were found. A correlation has been found between the in vitro cytotoxicity and DNA cleavage studies of the complexes.
Citace poskytuje Crossref.org
Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells
