Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21876505
PII: NEL320411A18
Knihovny.cz E-zdroje
- MeSH
- adiponektin krev MeSH
- dospělí MeSH
- ghrelin krev MeSH
- hluboká mozková stimulace metody MeSH
- hmotnostní přírůstek fyziologie MeSH
- hormony krev MeSH
- hydrokortison krev MeSH
- hypothalamus fyziologie MeSH
- inzulin krev MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- nucleus subthalamicus fyziologie MeSH
- Parkinsonova nemoc metabolismus terapie MeSH
- přijímání potravy fyziologie MeSH
- resistin krev MeSH
- senioři MeSH
- thyreotropin krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adiponektin MeSH
- ADIPOQ protein, human MeSH Prohlížeč
- ghrelin MeSH
- hormony MeSH
- hydrokortison MeSH
- inzulin MeSH
- leptin MeSH
- resistin MeSH
- RETN protein, human MeSH Prohlížeč
- thyreotropin MeSH
OBJECTIVES: Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones. DESIGN: Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation. RESULTS: Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2±(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested. CONCLUSIONS: Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation.
