Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21948563
DOI
10.1002/jcb.23380
Knihovny.cz E-resources
- MeSH
- Phosphatidylinositol 3-Kinase metabolism MeSH
- Cell Culture Techniques MeSH
- Chromones pharmacology MeSH
- Antigens, Differentiation genetics metabolism MeSH
- Embryonic Stem Cells drug effects metabolism physiology MeSH
- Transcription, Genetic MeSH
- Phosphoinositide-3 Kinase Inhibitors * MeSH
- Cadherins genetics metabolism MeSH
- Keratin-8 genetics metabolism MeSH
- Cells, Cultured MeSH
- Luciferases biosynthesis genetics MeSH
- Neural Cell Adhesion Molecules genetics metabolism MeSH
- Morpholines pharmacology MeSH
- Mice MeSH
- Neurogenesis drug effects MeSH
- Genes, Reporter MeSH
- Signal Transduction drug effects MeSH
- Tretinoin pharmacology MeSH
- Tubulin genetics metabolism MeSH
- Cell Shape drug effects MeSH
- Gene Expression Regulation, Developmental drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Phosphatidylinositol 3-Kinase MeSH
- 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MeSH Browser
- beta3 tubulin, mouse MeSH Browser
- Chromones MeSH
- Antigens, Differentiation MeSH
- Phosphoinositide-3 Kinase Inhibitors * MeSH
- Cadherins MeSH
- Keratin-8 MeSH
- Luciferases MeSH
- Neural Cell Adhesion Molecules MeSH
- Morpholines MeSH
- Tretinoin MeSH
- Tubulin MeSH
Retinoic acid (RA) is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling pre-determines mouse embryonic stem cells to RA induced neurogenesis in monolayer culture with no need of embryoid bodies formation.
References provided by Crossref.org
Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
Alkaline phosphatase in stem cells
Epigenetics and chromatin plasticity in embryonic stem cells
