Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.

Department of Molecular Biology and Cell Pathology 3rd Faculty of Medicine Charles University Prague Prague 10 Czech Republic

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The Prediction of Gestational Hypertension, Preeclampsia and Fetal Growth Restriction via the First Trimester Screening of Plasma Exosomal C19MC microRNAs

First trimester screening of circulating C19MC microRNAs and the evaluation of their potential to predict the onset of preeclampsia and IUGR

Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications

First trimester screening of circulating C19MC microRNAs can predict subsequent onset of gestational hypertension

Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction