A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22387280
DOI
10.1016/j.ijpharm.2012.02.023
PII: S0378-5173(12)00173-1
Knihovny.cz E-resources
- MeSH
- Surgical Mesh MeSH
- Chinchilla MeSH
- Tissue Fixation MeSH
- Hyperplasia pathology MeSH
- Immunohistochemistry MeSH
- Immunosuppressive Agents administration & dosage therapeutic use MeSH
- Rabbits MeSH
- Drug Implants MeSH
- Graft Occlusion, Vascular pathology prevention & control MeSH
- Cell Count MeSH
- Polyesters MeSH
- Cell Proliferation MeSH
- Proliferating Cell Nuclear Antigen metabolism MeSH
- Sirolimus administration & dosage therapeutic use MeSH
- Muscle, Smooth, Vascular drug effects MeSH
- Tunica Intima pathology MeSH
- Tunica Media pathology MeSH
- Veins transplantation MeSH
- Paraffin Embedding MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunosuppressive Agents MeSH
- Drug Implants MeSH
- Polyesters MeSH
- Proliferating Cell Nuclear Antigen MeSH
- Sirolimus MeSH
The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implanted v. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histological staining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 ± 11% or 73 ± 8% after 3 weeks, and by 73 ± 9% or 59 ± 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 ± 9% and 20 ± 12% after 3 and 6 weeks. The thickness of the intima-media complex in grafts with sirolimus-releasing meshes decreased by 60 ± 6% and 30 ± 13% in comparison with pure PES meshes, after 3 and 6 weeks, respectively. A periadventitial polyester mesh releasing sirolimus has the potential to become an effective device in preventing vein graft restenosis.
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