Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22403731
PubMed Central
PMC3293927
DOI
10.1371/journal.pone.0032972
PII: PONE-D-11-20329
Knihovny.cz E-zdroje
- MeSH
- apoptóza účinky léků účinky záření MeSH
- ethylenglykol chemie MeSH
- fotochemoterapie * MeSH
- genový knockdown MeSH
- homeostáza účinky léků účinky záření MeSH
- iniciační kaspasy metabolismus MeSH
- kaspasa 2 metabolismus MeSH
- kinasa eIF-2 nedostatek genetika metabolismus MeSH
- lidé MeSH
- mitogenem aktivované proteinkinasy p38 metabolismus MeSH
- nádorové buněčné linie MeSH
- porfyriny chemie farmakologie MeSH
- reaktivní formy kyslíku metabolismus MeSH
- signální transdukce účinky léků účinky záření MeSH
- stres endoplazmatického retikula účinky léků účinky záření MeSH
- subcelulární frakce účinky léků metabolismus účinky záření MeSH
- vápník metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CASP4 protein, human MeSH Prohlížeč
- ethylenglykol MeSH
- iniciační kaspasy MeSH
- kaspasa 2 MeSH
- kinasa eIF-2 MeSH
- mitogenem aktivované proteinkinasy p38 MeSH
- PERK kinase MeSH Prohlížeč
- porfyriny MeSH
- reaktivní formy kyslíku MeSH
- vápník MeSH
We have analyzed the molecular mechanisms of photoinduced cell death using porphyrins with similar structure differing only in the position of the ethylene glycol (EG) chain on the phenyl ring. Meta- and para-positioned EG chains targeted porphyrins to different subcellular compartments. After photoactivation, both types of derivatives induced death of tumor cells via reactive oxygen species (ROS). Para derivatives pTPP(EG)4 and pTPPF(EG)4 primarily accumulated in lysosomes activated the p38 MAP kinase cascade, which in turn induced the mitochondrial apoptotic pathway. In contrast, meta porphyrin derivative mTPP(EG)4 localized in the endoplasmic reticulum (ER) induced dramatic changes in Ca(2+) homeostasis manifested by Ca(2+) rise in the cytoplasm, activation of calpains and stress caspase-12 or caspase-4. ER stress developed into unfolded protein response. Immediately after irradiation the PERK pathway was activated through phosphorylation of PERK, eIF2α and induction of transcription factors ATF4 and CHOP, which regulate stress response genes. PERK knockdown and PERK deficiency protected cells against mTPP(EG)4-mediated apoptosis, confirming the causative role of the PERK pathway.
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