Impact of psychotropic drugs on adult hippocampal neurogenesis
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22414919
DOI
10.1016/j.neures.2012.02.014
PII: S0168-0102(12)00035-1
Knihovny.cz E-resources
- MeSH
- Emotions drug effects physiology MeSH
- Hippocampus cytology drug effects physiology MeSH
- Cognition drug effects physiology MeSH
- Humans MeSH
- Neurogenesis drug effects physiology MeSH
- Psychotropic Drugs pharmacology MeSH
- Aging drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Psychotropic Drugs MeSH
This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption.
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