Disorders of balance and gait in essential tremor are associated with midline tremor and age
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- akcelerometrie MeSH
- dospělí MeSH
- esenciální tremor diagnóza patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nemoci mozečku diagnóza patofyziologie MeSH
- neurodegenerativní nemoci diagnóza patofyziologie MeSH
- neurologické poruchy chůze diagnóza patofyziologie MeSH
- postura těla fyziologie MeSH
- posturální rovnováha fyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stárnutí fyziologie MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Disorders of balance and gait have been observed in patients with essential tremor (ET), but their association with tremor severity remains unclear. This study aimed to evaluate postural instability and gait changes in ET patients and to investigate their relationship to tremor characteristics with regard to cerebellar dysfunction as a possible common pathogenetic mechanism in ET. Thirty ET patients (8F, mean (SD) age 55.8 (17.8), range 19-81 years) and 25 normal controls (7F, 53.0 (17.7), 19-81) were tested with the scales of Activities-specific Balance Confidence (ABC), Fullerton Advanced Balance (FAB), and International Cooperative Ataxia Rating Scale (ICARS). Posturography and gait were assessed using a Footscan® system. Tremor was evaluated by the Fahn-Tolosa-Marin Tremor Rating Scale (TRS) and accelerometry in five upper limb positions. A mean (SD) TRS sum score of 27.0 (13.2) corresponded to mild to moderate tremor severity in most patients. In comparison with controls, ET subjects exhibited lower tandem gait velocity (0.21 vs. 0.26 m/s, P = 0.028), more missteps (0.57 vs. 0.12, P = 0.039), and increased postural sway in tandem stance (sway area 301.1 vs. 202.9 mm(2), P = 0.045). In normal gait, step width increased with the midline tremor subscore of TRS (Pearson r = 0.60, P = 0.046). Moreover, significant correlations were found between age and quantitative measures of normal and tandem gait in ET patients but not in controls. ABC, FAB, and ICARS scores did not significantly differ between patients and controls. In conclusion, gait and balance alterations in ET patients occur even without subjective complaints. Their relationship with midline tremor and dependence on age suggest a connection with cerebellar dysfunction.
Zobrazit více v PubMed
Mov Disord. 1997 Nov;12(6):969-72 PubMed
Cerebellum. 2007;6(1):79-86 PubMed
J Neurol Sci. 2010 Feb 15;289(1-2):144-8 PubMed
Cerebellum. 2011 Dec;10(4):812-9 PubMed
Arch Phys Med Rehabil. 2006 Nov;87(11):1478-85 PubMed
Mov Disord. 2009 Feb 15;24(3):386-91 PubMed
Mov Disord. 1998;13 Suppl 3:2-23 PubMed
J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):310-2 PubMed
Gait Posture. 2012 Jan;35(1):43-7 PubMed
Brain. 2010 Dec;133(Pt 12):3635-48 PubMed
Parkinsonism Relat Disord. 2011 Aug;17(7):516-20 PubMed
Mov Disord. 2010 Aug 15;25(11):1633-8 PubMed
Cerebellum. 2009 Sep;8(3):389-98 PubMed
Brain. 2001 Nov;124(Pt 11):2278-86 PubMed
AJNR Am J Neuroradiol. 2008 Oct;29(9):1692-7 PubMed
Med Biol Eng Comput. 2004 Jan;42(1):71-9 PubMed
Brain. 2007 Dec;130(Pt 12):3297-307 PubMed
Arch Phys Med Rehabil. 2006 Oct;87(10):1357-64 PubMed
Mov Disord. 2009 Oct 30;24(14):2033-41 PubMed
Mov Disord. 1994 Mar;9(2):193-6 PubMed
J Gerontol A Biol Sci Med Sci. 1995 Jan;50A(1):M28-34 PubMed
Arch Neurol. 2009 Oct;66(10):1202-8 PubMed
Mov Disord. 2006 Dec;21(12):2243-7 PubMed
Mov Disord. 2006 Feb;21(2):192-8 PubMed
Eur J Neurol. 2010 Oct;17(10):1291-7 PubMed
Neurology. 2000;54(11 Suppl 4):S2-6 PubMed
J Neurol Sci. 1997 Feb 12;145(2):205-11 PubMed
Gait Posture. 2011 May;34(1):65-70 PubMed
Neurological disorders of gait, balance and posture: a sign-based approach
