BACKGROUND, AIM AND SCOPE: The breast milk has been recommended to carry out as a monitoring tool for effectiveness evaluation of the Stockholm Convention on Persistent Organic Pollutants (POPs). Polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloro-ethane (DDT) and its metabolites (DDX), hexachlorbenzene (HCB) and isomers of hexachlocyklohexane (HCHs) have been monitored in the breast milk of nursing mothers in the Czech Republic since 1994 as a part of The Environmental Health Monitoring System. Knowledge about long-term POPs distribution and accumulation in the human body is crucial to understanding uptake, degradation and subsequent effects as well as to conduct risk assessments. The main aim of this study is to evaluate 15-years long-term trends of selected POPs in human milk in the Czech Republic and to elucidate the questionnaire information about the age, parity and social habits, to the final concentrations. This effectiveness evaluation of POPs restriction is quite precisely after 15-years monitoring campaigns. MATERIALS, METHODS AND RESULTS: The human milk samples (4,753 samples) were analysed for a number of chlorinated organic chemicals including PCBs and selected chlorinated pesticides (OCPs, HCB, HCHs, DDX). The relative change of concentration per year for all chemicals was analysed. The remaining percentages of POPs in breast milk in comparison to 1994 are also expressed. Czech population half-lives of POPs in breast milk, derived from either linear or exponential models were computed. CONCLUSIONS AND PERSPECTIVES: The long-term data indicates a continuation of a decreasing trend of POPs concentrations on breast milk. Our study did not confirm lactation and parity as an important outflux resulting in the decrease in concentrations in mothers, which is in the antagonism with most of the studies. The higher BMI was associated with higher amounts of HCB and lower amounts of higher chlorinated PCBs. The results confirm the effectiveness of restrictions of POPs usage in the Czech Republic. This ongoing long-term study is very useful tool for parametric effectiveness evaluation of Stockholm Convention.

Research Centre for Toxic compounds in the Environment Faculty of Science Masaryk University Brno Czech Republic

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J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):597-609 PubMed

Physiol Behav. 2008 Sep 3;95(1-2):118-24 PubMed

Chemosphere. 1996 Feb;32(3):543-9 PubMed

Environ Res. 2009 Aug;109(6):760-7 PubMed

Environ Sci Technol. 2010 Dec 15;44(24):9550-6 PubMed

J Pediatr. 1986 Aug;109(2):335-41 PubMed

Early Hum Dev. 2001 Nov;65 Suppl:S173-82 PubMed

J Expo Anal Environ Epidemiol. 2001 Sep-Oct;11(5):381-8 PubMed

AMA Arch Ind Hyg Occup Med. 1951 Mar;3(3):245-6 PubMed

Sci Total Environ. 2009 Aug 1;407(16):4584-90 PubMed

Chemosphere. 2001 Apr;43(2):243-56 PubMed

Paediatr Perinat Epidemiol. 2010 May;24(3):262-71 PubMed

Environ Health Perspect. 2009 Oct;117(10):1625-31 PubMed

Arch Environ Contam Toxicol. 1979;8(1):67-75 PubMed

Environ Res. 1999 Feb;80(2 Pt 2):S166-S174 PubMed

Arch Environ Contam Toxicol. 1997 Jul;33(1):97-103 PubMed

Chemosphere. 2001 May-Jun;43(4-7):889-93 PubMed

Environ Pollut. 2008 Nov;156(1):90-8 PubMed

Arch Environ Contam Toxicol. 1996 Feb;30(2):285-91 PubMed

Int J Hyg Environ Health. 2007 May;210(3-4):495-9 PubMed

Arch Environ Contam Toxicol. 1994 Oct;27(3):431-7 PubMed

Int J Hyg Environ Health. 2012 Feb;215(2):109-19 PubMed

Sci Total Environ. 1998 Apr 23;215(1-2):31-9 PubMed

Environ Health Perspect. 1994 Jan;102 Suppl 1:211-7 PubMed