There is substantial evidence in the literature that the basal ganglia (BG), namely the striatum and pallidum, are involved in temporal lobe epilepsy (TLE). The BG are probably not involved in elaborating clinical seizures, as they do not produce specific epileptiform activity and there is no evident change in the electrical activity in the BG immediately after seizure onset. The data we obtained by direct ictal recording in the BG [1,2], as well as a large body of experimental and clinical evidence reported by other groups, suggest an inhibitory role of the BG during temporal lobe seizures. The BG may have a remote influence on cortical oscillatory processes related to control of epileptic seizures via their feedback pathways to the cortex.

Central European Institute of Technology Masaryk University Brno Czech Republic

References provided by Crossref.org

Dorsal Striatum Is Compromised by Status Epilepticus Induced in Immature Developing Animal Experimental Model of Mesial Temporal Lobe Epilepsy

White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis

Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia

Third International Congress on Epilepsy, Brain and Mind: Part 1