Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cell Line MeSH
- Time Factors MeSH
- Photochemotherapy methods MeSH
- Indoles chemistry pharmacology MeSH
- Isoindoles MeSH
- Sulfonic Acids chemistry pharmacology MeSH
- Molecular Structure MeSH
- Brain MeSH
- Mice MeSH
- Neurons MeSH
- Prions drug effects MeSH
- Temperature MeSH
- Pressure MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- disulfonated hydroxyaluminium phthalocyanine MeSH Browser
- Indoles MeSH
- Isoindoles MeSH
- Sulfonic Acids MeSH
- phthalocyanine MeSH Browser
- Prions MeSH
Sulfonated phthalocyanines (Pcs) are cyclic tetrapyrroles that constitute a group of photosensitizers. In the presence of visible light and diatomic oxygen, Pcs produce singlet oxygen and other reactive oxygen species that have known degradation effects on lipids, proteins and/or nucleic acids. Pcs have been used successfully in the treatment of bacterial, yeast and fungal infections, but their use in the photodynamic inactivation of prions has never been reported. Here, we evaluated the photodynamic activity of the disodium salt of disulfonated hydroxyaluminium phthalocyanine (PcDS) against mouse-adapted scrapie RML prions in vitro. PcDS treatment of RML brain homogenate resulted in a time- and dose-dependent inactivation of prions. The photodynamic potential of Pcs offers a new way to inactivate prions using biodegradable compounds at room temperature and normal pressure, which could be useful for treating thermolabile materials and liquids.
References provided by Crossref.org
Prion Strains Differ in Susceptibility to Photodynamic Oxidation
