Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- HER2, androgen receptor, basal cytokeratins, basal-like phenotype, molecular subtypes, salivary duct carcinoma,
- MeSH
- androgenní receptory analýza biosyntéza genetika MeSH
- čipová analýza tkání MeSH
- dospělí MeSH
- duktální karcinom klasifikace genetika patologie MeSH
- fenotyp MeSH
- hybridizace in situ MeSH
- imunohistochemie MeSH
- karcinom in situ klasifikace genetika patologie MeSH
- karcinom klasifikace genetika patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- nádory slinných žláz klasifikace genetika patologie MeSH
- receptor erbB-2 analýza biosyntéza genetika MeSH
- sekvenční analýza hybridizací s uspořádaným souborem oligonukleotidů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- transkriptom MeSH
- vývody slinných žláz patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- androgenní receptory MeSH
- AR protein, human MeSH Prohlížeč
- ERBB2 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
- receptor erbB-2 MeSH
AIMS: The aim of this study was to devise a molecular classification for salivary duct carcinomas (SDCs) based on the similarities between SDCs and breast carcinomas and on characteristics of the microarray-based gene expression profiling-defined molecular subtypes of breast cancer. METHODS AND RESULTS: Forty-two pure salivary duct carcinomas, 35 of which contained an in-situ component as defined by histological review and/or immunohistochemical analysis, were stained with antibodies for oestrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5/6. Based on these markers, tumours were classified into HER2, luminal androgen receptor-positive, basal-like, luminal and indeterminate phenotype. Analysis revealed that 16.7%, 69%, 4.8%, 9.5% and 0% were of HER2, luminal androgen receptor-positive, basal-like, indeterminate and luminal phenotype, respectively. The in-situ and invasive components displayed the same molecular subtype in all but one case. CONCLUSION: Salivary duct carcinomas can be classified into molecular subgroups approximately equivalent to those in the breast. We also report on the existence of a subgroup of bona fide pure salivary duct carcinomas that have a 'basal-like' phenotype. Understanding the phenotypic complexity of SDCs may help to expedite the identification of novel therapeutic targets for these aggressive tumours.
Citace poskytuje Crossref.org
Development of head and neck pathology in Europe
