Impact of maternally-derived antibodies against Salmonella enterica serovar Typhimurium on the bacterial load in suckling piglets
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22967925
DOI
10.1016/j.tvjl.2012.08.002
PII: S1090-0233(12)00343-7
Knihovny.cz E-resources
- MeSH
- Bacterial Load veterinary MeSH
- Bacterial Vaccines immunology MeSH
- Cecum microbiology MeSH
- Ileum microbiology MeSH
- Immunity, Maternally-Acquired * MeSH
- Immunoglobulin A blood MeSH
- Immunoglobulin G blood MeSH
- Vaccines, Inactivated immunology MeSH
- Colostrum immunology MeSH
- Milk immunology MeSH
- Swine Diseases immunology microbiology MeSH
- Animals, Newborn MeSH
- Swine MeSH
- Salmonella typhimurium immunology MeSH
- Salmonella Infections, Animal immunology microbiology MeSH
- Immunity, Mucosal MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bacterial Vaccines MeSH
- Immunoglobulin A MeSH
- Immunoglobulin G MeSH
- Vaccines, Inactivated MeSH
The significance of maternal immunity against non-typhoid Salmonella spp. acquired by piglets via colostrum and milk was evaluated in a Salmonella enterica serovar Typhimurium challenge experiment. Piglets from sows vaccinated with an experimental inactivated vaccine exhibited high levels of serum immunoglobulins G and A against S. Typhimurium 4 days after birth, just prior to experimental oral challenge. The S. Typhimurium load in the ileal and caecal wall of piglets 3 days after experimental inoculation was lower by a 2-log magnitude compared to unvaccinated controls. Such a vaccine, delivering colostral/lactogenic immunity to piglets thus has the potential to reduce the prevalence non-typhoid Salmonella spp. infection.
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