Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Autoantibodies blood MeSH
- Biomarkers blood MeSH
- Peptides, Cyclic immunology MeSH
- Cytokines blood MeSH
- Adult MeSH
- Interleukin-15 blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Disease Progression MeSH
- Radiography MeSH
- Arthritis, Rheumatoid blood diagnostic imaging immunology MeSH
- ROC Curve MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Biomarkers MeSH
- cyclic citrullinated peptide MeSH Browser
- Peptides, Cyclic MeSH
- Cytokines MeSH
- IL15 protein, human MeSH Browser
- Interleukin-15 MeSH
The aim of study was to examine relationship among levels of cytokines (IL-6, IL-13, IL-15, TNF-α) and chemokine (IL-8), production of autoantibodies, radiographic progression, and factors describing rheumatoid arthritis (RA). A total of 156 RA patients according to ACR criteria, and 55 control subjects were recruited into study. We observed higher levels of IL-15 within RA patients compared to healthy controls. Correlations among cytokine levels and the measures of rheumatoid factors, anti-CCP, measures of disease activity, and radiographic progression were observed. We conclude that IL-15 level in circulation could serve as one of the biomarkers for RA detection.
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