Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23121971
DOI
10.1016/j.cellimm.2012.06.004
PII: S0008-8749(12)00116-5
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation MeSH
- Virus Activation MeSH
- Antigens, CD1d genetics immunology MeSH
- Adult MeSH
- Gene Expression MeSH
- Herpes Simplex immunology pathology virology MeSH
- NK Cell Lectin-Like Receptor Subfamily K genetics immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Natural Killer T-Cells immunology pathology MeSH
- Immunity, Innate * MeSH
- Aged MeSH
- Simplexvirus physiology MeSH
- Tumor Necrosis Factor-alpha genetics immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, CD1d MeSH
- KLRK1 protein, human MeSH Browser
- NK Cell Lectin-Like Receptor Subfamily K MeSH
- Tumor Necrosis Factor-alpha MeSH
Invariant natural killer T (iNKT) cells, CD1d restricted T cells, are involved in the immune responses against various infection agents. Here we describe their behavior during reactivation of human herpes simplex virus (HSV). iNKT cells exhibit only discrete changes, which however, reached statistically significant level due to the relatively large patient group. Higher percentage of iNKT cells express NKG2D. iNKT cells down-regulate NKG2A in a subset of patients. Finally, iNKT cells enhance their capacity to produce TNF-α. Our data suggests that iNKT cells are involved in the immune response against HSV and contribute mainly to its early, innate phase.
References provided by Crossref.org
