Effects of microbial elicitor on production of hypocrellin by Shiraia bambusicola
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Infective Agents metabolism MeSH
- Ascomycota metabolism MeSH
- Biotechnology methods MeSH
- Quinones metabolism MeSH
- DNA, Fungal chemistry genetics MeSH
- Phenol MeSH
- Fermentation MeSH
- Culture Media chemistry MeSH
- DNA, Ribosomal Spacer chemistry genetics MeSH
- Molecular Sequence Data MeSH
- Perylene analogs & derivatives metabolism MeSH
- Sequence Analysis, DNA MeSH
- Trametes classification genetics growth & development isolation & purification MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Quinones MeSH
- DNA, Fungal MeSH
- Phenol MeSH
- hypocrellin A MeSH Browser
- Culture Media MeSH
- DNA, Ribosomal Spacer MeSH
- Perylene MeSH
Some endophyte isolates were isolated in a bamboo pole sample parasitized the fungus Shiraia bambusicola from Zhejiang Province. After screening through hypocrellin bacteriostatic effect and fermentation test, we got the isolate TX4 of bacterial elicitor and GZUIFR-TT1 of fungal elicitor which had certain effect to promote S. bambusicola to produce hypocrellin. The Plackett-Burman design was introduced to evaluate the effects of nine factors based on single-factor test. Yeast extract, glucose, and isolate GZUIFR-TT1 elicitor were found to be the critical activity factors for increasing the total hypocrellin production. So we identified the isolate GZUIFR-TT1 as Trametes sp. Through response surface methodology, we obtained the optimum production conditions as follows: yeast extract, 2.99 g/L; glucose, 32.45 g/L; and Trametes sp. elicitor, 81.40 μg/mL. Under the above conditions, the experimental value of hypocrellin production was 102.60 mg/L, compared with the control it increased about 7.90 times.
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