Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adaptor Proteins, Signal Transducing MeSH
- Biomarkers blood MeSH
- C-Reactive Protein metabolism MeSH
- Adult MeSH
- Genetic Markers MeSH
- Glucocorticoids pharmacology therapeutic use MeSH
- Collagen Type I blood MeSH
- Bone Morphogenetic Proteins blood MeSH
- Middle Aged MeSH
- Humans MeSH
- RANK Ligand blood MeSH
- Intercellular Signaling Peptides and Proteins blood MeSH
- Osteoblasts drug effects metabolism MeSH
- Osteocytes drug effects metabolism MeSH
- Osteocalcin blood MeSH
- Osteoclasts drug effects metabolism MeSH
- Osteoprotegerin blood MeSH
- Peptide Fragments blood MeSH
- Peptides blood MeSH
- Procollagen blood MeSH
- Prospective Studies MeSH
- Rheumatic Diseases blood drug therapy pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adaptor Proteins, Signal Transducing MeSH
- Biomarkers MeSH
- C-Reactive Protein MeSH
- collagen type I trimeric cross-linked peptide MeSH Browser
- DKK1 protein, human MeSH Browser
- Genetic Markers MeSH
- Glucocorticoids MeSH
- Collagen Type I MeSH
- Bone Morphogenetic Proteins MeSH
- RANK Ligand MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Osteocalcin MeSH
- Osteoprotegerin MeSH
- Peptide Fragments MeSH
- Peptides MeSH
- procollagen Type I N-terminal peptide MeSH Browser
- Procollagen MeSH
- SOST protein, human MeSH Browser
The aim of this study was to investigate the acute effects of oral glucocorticoids in doses used in clinical practice on biochemical indices of the function of osteoclasts, osteoblasts, and osteocytes. In 17 adult patients suffering from various medical pathologies requiring systemic steroid therapy that were never before treated with glucocorticoids, glucocorticoid treatment was initiated (mean prednisolone equivalent dose of 23.1 ± 12.7 mg/day, range 10-50). Fasting morning serum concentrations of osteocalcin (OC), amino-terminal propeptide of type I procollagen (PINP), type 1 collagen cross-linked C-telopeptide (βCTX), soluble receptor activator of nuclear factor kappaB ligand (sRANKL), osteoprotegerin (OPG), sclerostin, Dickkopf-1 (Dkk-1), and high-sensitivity C-reactive protein (hsCRP) were measured at baseline and on three consecutive days. Significant reductions in serum OC, PINP, OPG, sclerostin, and hsCRP were observed during 96 h of glucocorticoid administration, while serum βCTX showed a significant percentual increase. A significant positive correlation was found between serum concentrations of Dkk-1 and βCTX after 96 h of treatment with glucocorticoids. A significant drop in serum sclerostin, OPG, and OC observed in this study may reflect the rapid glucocorticoid-induced apoptosis of osteocytes.
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