Can repetitive transcranial magnetic stimulation be considered effective treatment option for negative symptoms of schizophrenia?
Language English Country United States Media print
Document type Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review
- MeSH
- Patient Compliance MeSH
- Double-Blind Method MeSH
- Clinical Trials as Topic MeSH
- Humans MeSH
- Cerebral Cortex anatomy & histology MeSH
- Randomized Controlled Trials as Topic MeSH
- Schizophrenic Psychology MeSH
- Schizophrenia therapy MeSH
- Transcranial Magnetic Stimulation methods MeSH
- Age Factors MeSH
- Treatment Outcome MeSH
- Research Design MeSH
- Dose-Response Relationship, Radiation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
OBJECTIVE: Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making. METHOD: Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011. RESULTS: Five open studies, 13 sham-controlled studies, and 2 meta-analysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43-0.68). CONCLUSION: Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies.
References provided by Crossref.org
