Compartmentalized and internally structured particles for drug delivery--a review
Language English Country United Arab Emirates Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
23470000
DOI
10.2174/1381612811319350007
PII: CPD-EPUB-20130304-3
Knihovny.cz E-resources
- MeSH
- Pharmaceutical Preparations administration & dosage chemistry MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Microspheres MeSH
- Nanoparticles MeSH
- Silicon Dioxide chemistry MeSH
- Polymers chemistry MeSH
- Porosity MeSH
- Drug Compounding methods MeSH
- Drug Design MeSH
- Particle Size MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Pharmaceutical Preparations MeSH
- Silicon Dioxide MeSH
- Polymers MeSH
Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random pore structure, as well as complex composite particles possessing several of the above features. Particles based on "hard" inorganic materials such as silica, "soft" organic materials such as polymers and their composites are considered. The fabrication approaches include bottom-up self-assembly techniques, templating methods, microfluidics, and various emulsion-based routes to structured micro- and nano-particle formation, combined with both physical (e.g. Pickering emulsions) and chemical (e.g. polymerization, precipitation) processes for the material deposition. The applications of the structured particles for the encapsulation and controlled delivery of active substances are then reviewed with emphasis on those systems where the complex particle structure can provide specific benefits such as in-situ formation of the active substance or precise control over the release profile. Likely future research directions and prospects are discussed.
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