Auxarthron ostraviense sp. nov., and A. umbrinum associated with non-dermatophytic onychomycosis
Language English Country England, Great Britain Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antifungal Agents pharmacology MeSH
- DNA, Fungal chemistry genetics MeSH
- Adult MeSH
- Fungal Proteins genetics MeSH
- Clotrimazole pharmacology MeSH
- Middle Aged MeSH
- Humans MeSH
- DNA, Ribosomal Spacer chemistry genetics MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Sequence Data MeSH
- Naphthalenes pharmacology MeSH
- Onychomycosis microbiology MeSH
- Onygenales classification genetics isolation & purification MeSH
- Psoriasis complications MeSH
- Sequence Analysis, DNA MeSH
- Terbinafine MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- DNA, Fungal MeSH
- Fungal Proteins MeSH
- Clotrimazole MeSH
- DNA, Ribosomal Spacer MeSH
- Naphthalenes MeSH
- Terbinafine MeSH
Auxarthron is a genus within the Onygenales encompassing keratinophilic species with typical ascomata (gymnothecia) consisting of anastomosing network of thick-walled hyphae and small globose or oblate ascospores. No association of this genus with clinically relevant cases of human or animal infection has been reported. This paper describes the isolation of an undescribed Auxarthron species as an agent of proven onychomycosis affecting almost all fingernails in a man with psoriasis. The causality of the isolated fungus was verified by repeated sampling and direct microscopy revealing irregular septate hyphae. Based on micro- and macromorphological features and unique sequence data (ITS region, benA and RPB2 gene), the isolated fungus is proposed as the new species A. ostraviense. The sibling species of A. ostraviense, A. umbrinum, was isolated from three patients with suspected onychomycosis and a detailed clinical history is provided for one of these patients. All four isolates were tested for susceptibility to selected antifungal agents. Terbinafine and clotrimazole appear to be effective in vitro. The morphological identification of Auxarthron spp. is non-trivial, time-consuming and requires cultivation media other than Sabouraud glucose agar which is routinely used in dermatomycology.
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GENBANK
HE974411, HE974417, HE974452
