BACKGROUND: The dipeptidyl peptidase-IV (DPP-IV) family has outgrown its humble origins as a simple enzymatic activity cleaving dipeptides from peptides with an accessible N-terminal penultimate proline with no clear role in metabolism. It is now understood to play a critical role in regulating signaling capacity of chemokines, neuropeptides and other extracellular messengers in addition to playing direct roles by means of non-enzymatic interactions to regulate the local extracellular proliferative environment. Consequently, examination of DPP-IV family representation and activity in immune and oncogenic processes has become a major focus. OBJECTIVES: To review the evidence for DPP-IV family members as markers of malignancy. METHODS: Overview of published data. RESULTS/CONCLUSION: The DPP-IV family, which is probably linked directly to the pathogenesis of cancer, holds significant promise for exploitation in the diagnostic arena.

Charles University Prague Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine U Nemocnice 5 128 53 Prague 2 Czech Republic 420 728 748 692 ; 420 224 965 826 ;

Citace poskytuje Crossref.org

Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease?