Chemicals in air were characterized for potential interference with signaling of estrogen, androgen, and arylhydrocarbon (AhR) receptors, which are known to play an important role in endocrine-disruptive changes in vivo. Previously, effects of this type have been studied mainly in particulate matter in the ambient air from various localities. In this study, both volatile and particulate fractions of air from three sites in Banja Luka region (Bosnia and Herzegovina) were investigated to describe the distribution of endocrine-disrupting contaminants on a small spatial scale. Circadian variability of air pollution was investigated by collecting samples during both day and night. Air samples collected from urban localities at night were more potent in producing the AhR-mediated effects than those collected during daytime. This trend was not observed at the reference rural location. None of the samples showed significant estrogenic or androgenic activity. On the other hand, anti-androgenicity was detected in both particulate and vapor phases, while anti-estrogenicity was detected only in the particulate fraction of air from all localities. The AhR-mediated potencies of samples were associated primarily with non-persistent compounds. Based on the concentrations of 28 individual compounds, PAHs accounted for approximately 30 % of the AhR-mediated potency determined by the bioassay. The results show that there can be a significant difference between levels of bioactive compounds in air between daytime and nighttime.

Research Centre for Toxic Compounds in the Environment Faculty of Science Masaryk University Kamenice 5 625 00 Brno Czech Republic

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Arch Environ Contam Toxicol. 2004 May;46(4):454-62 PubMed

Toxicology. 1999 Apr 15;133(2-3):115-27 PubMed

Toxicol Appl Pharmacol. 1996 Apr;137(2):316-25 PubMed

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Toxicol In Vitro. 2006 Feb;20(1):18-37 PubMed

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J Environ Monit. 2009 Nov;11(11):1952-63 PubMed

Atmos Environ (1994). 2009 Jan 1;43(1):170-181 PubMed

Atmos Pollut Res. 2010 Jan 1;1(1):50-58 PubMed

J Appl Toxicol. 2009 Apr;29(3):223-32 PubMed

Environ Sci Technol. 2003 Oct 15;37(20):4543-53 PubMed

J Air Waste Manag Assoc. 1998 Feb;48(2):157-65 PubMed

Nature. 2003 May 29;423(6939):545-50 PubMed

J Toxicol Environ Health A. 2006 Jan 8;69(1-2):53-76 PubMed

Sci Total Environ. 2008 Oct 1;404(1):26-35 PubMed

Environ Health Perspect. 1998 Aug;106 Suppl 4:1051-8 PubMed

Mutat Res. 2001 Oct 18;497(1-2):49-62 PubMed

Toxicol Lett. 2005 Jan 15;155(1):1-13 PubMed

Toxicol Sci. 2011 May;121(1):88-100 PubMed

Arch Environ Contam Toxicol. 2005 May;48(4):459-66 PubMed

Environ Toxicol Chem. 2007 Jul;26(7):1370-9 PubMed

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Anal Bioanal Chem. 2009 Jul;394(5):1413-21 PubMed

Environ Pollut. 2010 Oct;158(10):3230-5 PubMed

Sci Total Environ. 2004 Dec 1;334-335:141-8 PubMed

Chemosphere. 1997 Feb;34(4):835-48 PubMed

Environ Health Perspect. 2004 Apr;112(5):524-31 PubMed

J Steroid Biochem Mol Biol. 1993 Sep;46(3):355-64 PubMed

Sci Total Environ. 2005 Oct 15;349(1-3):161-74 PubMed

Environ Int. 2006 Aug;32(6):815-30 PubMed

Environ Health Perspect. 1994 Oct;102 Suppl 4:111-6 PubMed

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jun;43(7):675-81 PubMed

J Environ Monit. 2007 Jun;9(6):557-63 PubMed

Environ Pollut. 2009 Apr;157(4):1323-31 PubMed

Environ Int. 2009 Jan;35(1):43-9 PubMed

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Environ Toxicol. 2002;17(2):128-37 PubMed