Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23632043
DOI
10.1016/j.jneuroim.2013.03.009
PII: S0165-5728(13)00080-5
Knihovny.cz E-resources
- MeSH
- Autoantibodies blood cerebrospinal fluid immunology MeSH
- Early Diagnosis MeSH
- Adult MeSH
- Immunoglobulin G blood cerebrospinal fluid immunology MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Young Adult MeSH
- Neurofilament Proteins immunology MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Multiple Sclerosis, Relapsing-Remitting diagnosis epidemiology immunology MeSH
- Seroepidemiologic Studies MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Immunoglobulin G MeSH
- neurofilament protein H MeSH Browser
- Neurofilament Proteins MeSH
Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.
References provided by Crossref.org
Impaired intestinal permeability in patients with multiple sclerosis
