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Clinical and laboratory characteristics of 1179 Czech adolescents evaluated for antibodies to human adenovirus 36

Aldhoon-Hainerová, I
Author Aldhoon-Hainerová, I ] Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic [2] Department of Pediatrics and Center for Research of Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
Zamrazilová, H
Author Zamrazilová, H Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic
Atkinson, R L
Author Atkinson, R L Obetech Obesity Research Center, Richmond, VA, USA
Dušátková, L
Author Dušátková, L ] Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic [2] Faculty of Science, Charles University, Prague, Czech Republic
Sedláčková, B
Author Sedláčková, B ] Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic [2] Faculty of Science, Charles University, Prague, Czech Republic
Hlavatý, P
Author Hlavatý, P Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic
Lee, Z P
Author Lee, Z P Obetech Obesity Research Center, Richmond, VA, USA
Kunešová, M
Author Kunešová, M Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic
Hainer, V
Author Hainer, V Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic

International journal of obesity (2005). 2014 Feb ; 38 (2) : 285-91. [epub] 20130514

Int J Obes (Lond)
ISSN 1476-5497 | 0307-0565
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid23732656

PubMed 23732656
DOI 10.1038/ijo.2013.72
PII: ijo201372
Knihovny.cz E-resources

MeSH
Adenovirus E1B Proteins immunology metabolism MeSH
Adiponectin blood MeSH
Biomarkers blood MeSH
Enzyme-Linked Immunosorbent Assay MeSH
Body Mass Index MeSH
Insulin blood MeSH
Blood Glucose metabolism MeSH
Blood Pressure MeSH
Cholesterol, LDL blood MeSH
Humans MeSH
Adenoviruses, Human immunology MeSH
Adolescent MeSH
Disease Susceptibility MeSH
Pediatric Obesity epidemiology immunology virology MeSH
Odds Ratio MeSH
Peptide Fragments immunology metabolism MeSH
Waist-Hip Ratio MeSH
Antibodies, Viral blood MeSH
Risk Factors MeSH
Body Composition MeSH
Triglycerides blood MeSH
Check Tag
Humans MeSH
Adolescent MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Geographicals
Czech Republic MeSH
Names of Substances
Adenovirus E1B Proteins MeSH
adenovirus E1B protein (368-381) MeSH Browser
Adiponectin MeSH
Biomarkers MeSH
Insulin MeSH
Blood Glucose MeSH
Cholesterol, LDL MeSH
Peptide Fragments MeSH
Antibodies, Viral MeSH
Triglycerides MeSH

BACKGROUND: Human adenovirus 36 (Adv36) is associated with obesity in children. Most prior studies have been small and the association of Adv36 status with markers of metabolic risks has been inconsistent. OBJECTIVES: To determine the prevalence of Adv36 antibodies in different weight categories of adolescents and to evaluate the association of Adv36 infection with anthropometric parameters and cardiometabolic health risks. SUBJECTS AND METHODS: In 1179 Czech adolescents (85 underweight, 506 normal weight, 160 overweight and 428 obese), the following variables were evaluated: anthropometric (body weight, height, body mass index, circumferences, fat mass), blood pressure, biochemical and hormonal (lipid profile, glucose, insulin, liver enzymes, adiponectin) and Adv36 antibodies (enzyme-linked immunosorbent assay). RESULTS: Of the total cohort, 26.5% were positive for Adv36 antibodies (underweight: 22.3%; normal weight: 21.5%; overweight: 40.0% and obese: 28.0%). The odds ratio for Adv36 antibody positivity evaluated vs normal weight was 2.61 for overweight (95% confidence interval (CI): 1.77-3.86, P<0.001) and 1.46 for obesity (95% CI: 1.07-1.99, P=0.016). A significantly higher prevalence of Adv36 infection was observed in female subjects (32.5%) in comparison to male subjects (19.7%; P<0.001). Adv36 positivity of the whole cohort was significantly related to body weight (P=0.042), body mass index (P=0.015), hip circumference (P=0.004), body height z-score (P=0.029), and total body fat (P=0.000) and trunk fat (P=0.000). Adv36 antibody-positive girls demonstrated significantly higher body height (167.8 vs 165.0 cm, P=0.01) and waist circumference (77.0 vs 72.0 cm, P=0.01). Infected adolescents exhibited significantly higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), but lower levels of blood glucose. Liver enzymes were significantly increased only in Adv36-positive boys. CONCLUSION: These results demonstrated an association of Adv36 antibodies with obesity and an even greater association with overweight. Adv36 positivity was related to increased fat mass, levels of TC and LDL-C, but to decreased level of blood glucose. No relation to adiponectin levels was revealed.

] Obesity Management Center Institute of Endocrinology Prague Czech Republic [2] Department of Pediatrics and Center for Research of Diabetes Metabolism and Nutrition 3rd Faculty of Medicine Charles University Prague Czech Republic

] Obesity Management Center Institute of Endocrinology Prague Czech Republic [2] Faculty of Science Charles University Prague Czech Republic

Obesity Management Center Institute of Endocrinology Prague Czech Republic

Obetech Obesity Research Center Richmond VA USA

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