BACKGROUND: Langerhans cell histiocytosis is a rare disease characterized by monoclonal proliferation and migration of special dendritic cells. This disease primarily affects bones, but occurs less frequently in other organ systems or may manifest as a multisystem disease. CASE REPORTS: Extraoral and intraoral symptoms of Langerhans cell histiocytosis are described in a 13-month-old female and a 5-month-old male infant. Dermatitis was found on the scalp, abdomen, flexures and in intertrigineous areas in both patients. The intraoral examination of the 13-month-old infant showed premature eruption of all maxillary deciduous molars, loosening and significant damage of periodontal tissues (gingivitis with bleeding, swelling of palatal mucosa, periodontal pockets) resembling severe periodontitis. In the oral cavity of the 5-month-old predentate infant bilateral swellings of maxillary alveolar mucosa with deep ulcerations were seen. The oral and skin symptoms in both infants were indications for biopsy. Langerhans cell histiocytosis was confirmed histologically and immunohistochemically. CONCLUSION: Oral findings in Langerhans cell histiocytosis may be the only clinical symptom of the disease; therefore the role of dentists in establishing diagnosis is very important.

Department of Dentistry University Hospital and Faculty of Medicine in Pilsen Charles University Prague Alej Svobody 80 304 60 Pilsen Czech Republic

Department of Oral and Maxillofacial Surgery University Hospital and Faculty of Medicine in Pilsen Charles University Prague Alej Svobody 80 304 60 Pilsen Czech Republic

Sikl's Department of Pathology University Hospital and Faculty of Medicine in Pilsen Charles University Prague Dr Edvarda Benese 13 305 99 Pilsen Czech Republic

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