Objective acoustic quantification of phonatory dysfunction in Huntington's disease
Jazyk angličtina Země Spojené státy americké Médium electronic-print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
23762447
PubMed Central
PMC3677914
DOI
10.1371/journal.pone.0065881
PII: PONE-D-13-05826
Knihovny.cz E-zdroje
- MeSH
- akustika řeči * MeSH
- dospělí MeSH
- fonace * MeSH
- Huntingtonova nemoc komplikace patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- poruchy hlasu diagnóza etiologie MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
PURPOSE: Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD. METHOD: 34 subjects with HD and 34 age- and sex-matched healthy controls were examined. Participants performed sustained vowel phonation for subsequent analyses of airflow insufficiency, aperiodicity, irregular vibrations of vocal folds, signal perturbations, increased noise, and articulation deficiency. In total, 272 phonations were collected and 12 voice parameters were extracted. Subsequently, a predictive model was built to find the most salient patterns of voice disorders in HD. The results were also correlated with disease severity according to the Unified HD Rating Scale (UHDRS) motor score. RESULTS: Subjects with HD showed deterioration in all investigated phonatory functions. Irregular pitch fluctuations, sudden phonation interruption, increased noise, and misplacement of articulators were found to be most significant patterns of phonatory dysfunction in HD (p<0.001). The combination of these four dysphonia aspects contributed to the best classification performance of 94.1% (sensitivity: 95.1%; specificity: 93.2%) in the separation of HD patients from healthy participants. Our results further indicated stronger associations between sudden phonation interruption and voluntary components of the UHDRS (r = -0.48, p<0.01) and between misplacement of articulators and involuntary components of the UHDRS (r = 0.52, p<0.01). CONCLUSIONS: Our configuration of phonatory features can detect subtle voice abnormalities in subjects with HD. As impairment of phonatory function in HD was found to parallel increasing motor involvement, a qualitative description of voice dysfunction may be helpful to gain better insight into the pathophysiology of the vocal mechanism.
PLoS One. 2013;8(9). doi:10.1371/annotation/a1ee87ea-1fdb-4baa-a8b0-62a44342f3cc PubMed
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Phonatory dysfunction as a preclinical symptom of Huntington disease
A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse