Haplotypes of the IL-1 gene cluster are associated with gastroesophageal reflux disease and Barrett's esophagus
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23806268
DOI
10.1016/j.humimm.2013.06.026
PII: S0198-8859(13)00183-3
Knihovny.cz E-resources
- Keywords
- BE, Barrett’s esophagus, CI, DNA, DU, EAC, EC, EE, GAC, GERD, GIQLI, GU, HWE, Hardy–Weinberg equilibrium, IL-1, LD, LES, NERD, OR, PCR, RE, RFLP, SNP, VNTR, adenocarcinoma of the esophagus, confidence intervals, deoxyribonucleic acid, duodenal ulcer, erosive esophagitis, esophageal cancer, gastric adenocarcinoma, gastric ulcer, gastroesophageal reflux disease, gastrointestinal quality of life index, interleukin-1, linkage disequilibrium, lower esophageal sphincter, non-erosive reflux disease, odds ratio, polymerase chain reaction, reflux esophagitis, restriction fragment length polymorphism, single nucleotide polymorphism, variable number tandem repeat,
- MeSH
- Barrett Esophagus genetics immunology MeSH
- Adult MeSH
- Gene Frequency MeSH
- Gastroesophageal Reflux genetics immunology MeSH
- Genetic Association Studies MeSH
- Genotype MeSH
- Haplotypes MeSH
- Interleukin-1 genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Multigene Family immunology MeSH
- Case-Control Studies MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Interleukin-1 MeSH
OBJECTIVES: Gastroesophageal reflux (GERD) is a one of the major public health problem that can lead to reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC). The aim of our study was to determine the impact of IL-1 gene polymorphisms on the development of GERD, RE and BE. METHODS: Three hundred and thirty-three Czech patients with gastroesophageal reflux and 165 healthy controls were included in this case-control study. Four polymorphisms in the genes of the IL-1 cluster [IL-1A(-889C/T), IL-1B(-511C/T), IL-1B(+3953C/T), and IL-1RN(VNTR)] were analyzed. RESULTS: Significant differences were found in IL-1RN 1/2 genotype between patients with GERD/RE and controls and in IL-1B+3953 T allele between patients with BE and healthy subjects. In addition, complex analysis revealed differences in IL-1 haplotype frequencies between the groups. Specifically, the haplotype TCCL was significantly more frequent (p = 0.016) in GERD patients than in controls and the haplotype CCCL more frequent (p = 0.008) in RE patients than in controls. However, in patients with BE, frequency of haplotype TCTL was lower (p = 0.05) and haplotypes CTCL and TCCL were higher (p = 0.03 and p = 0.02) in comparison with the controls. CONCLUSIONS: Our results suggest that IL-1 haplotypes may be associated with susceptibility to GERD, RE and BE.
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