Correlation between the activity of digestive enzymes and nonself recognition in the gut of Eisenia andrei earthworms
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23999244
DOI
10.1016/j.jip.2013.08.003
PII: S0022-2011(13)00116-X
Knihovny.cz E-resources
- Keywords
- Digestive enzyme, Earthworm, Eisenia andrei, Gut, Innate immunity, Microbiota,
- MeSH
- Bacillus subtilis immunology MeSH
- Cellulases metabolism MeSH
- Escherichia coli immunology MeSH
- Hexosaminidases metabolism MeSH
- RNA, Messenger metabolism MeSH
- Muramidase metabolism physiology MeSH
- Oligochaeta enzymology immunology microbiology MeSH
- Immunity, Innate MeSH
- Peptide Hydrolases metabolism MeSH
- Saccharomyces cerevisiae immunology MeSH
- Up-Regulation MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cellulases MeSH
- Hexosaminidases MeSH
- RNA, Messenger MeSH
- Muramidase MeSH
- Peptide Hydrolases MeSH
Earthworms Eisenia andrei, similarly to other invertebrates, rely on innate defense mechanisms based on the capability to recognize and respond to nonself. Here, we show a correlation between the expression of CCF, a crucial pattern-recognition receptor, and lysozyme, with enzyme activities in the gut of E. andrei earthworms following a microbial challenge. These data suggest that enzyme activities important for the release and recognition of molecular patterns by pattern-recognition molecules, as well as enzymes involved in effector pathways, are modulated during the microbial challenge. In particular, protease, laminarinase, and glucosaminidase activities were increased in parallel to up-regulated CCF and lysozyme expression.
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