Prediction of compartment syndrome based on analysis of biochemical parameters
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24011810
DOI
10.1016/j.avsg.2012.12.006
PII: S0890-5096(13)00322-1
Knihovny.cz E-resources
- MeSH
- Acute Disease MeSH
- Biomarkers blood MeSH
- Time Factors MeSH
- Embolectomy adverse effects MeSH
- Embolism diagnosis surgery MeSH
- Ischemia diagnosis surgery MeSH
- Compartment Syndromes blood diagnosis etiology surgery MeSH
- Lactic Acid blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Predictive Value of Tests MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Risk Factors MeSH
- Aged MeSH
- Femoral Vein MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Lactic Acid MeSH
BACKGROUND: The possibility of predicting severe compartment syndrome using simple biochemical parameters was evaluated in a single-center study of 55 patients who presented with acute femoral embolism and who were treated with open surgical embolectomy. METHODS: Parameters related to tissue damage and oxidative metabolism (i.e., lactate, bilirubin, myoglobin, uric acid, glucose, and fibrinogen) were monitored in ipsilateral femoral vein blood. RESULTS: Several statistically significant predictors of relevant compartment syndrome after surgical reperfusion were found, including lactate, uric acid, transcutaneous oxygen pressure, bilirubin, intrafascial pressure, and serum myoglobin. Glycemia and serum albumin did not significantly change over time. CONCLUSIONS: The lactate concentration in femoral vein blood sampled during surgical embolectomy can be used for the stratification of additional postoperative risk of clinically significant compartment syndrome complicating reperfusion after acute embolism of the femoral artery.
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