Tagging rs10811661 variant at CDKN2A/2B locus is not associated with type 2 diabetes mellitus in Czech population
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24093775
PII: file/5697/FB2013A0024.pdf
Knihovny.cz E-resources
- MeSH
- Diabetes Mellitus, Type 2 genetics MeSH
- Adult MeSH
- Gene Frequency genetics MeSH
- Genetic Predisposition to Disease * MeSH
- Genetic Loci genetics MeSH
- Cyclin-Dependent Kinase Inhibitor p15 genetics MeSH
- Cyclin-Dependent Kinase Inhibitor p16 genetics MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Models, Genetic MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- CDKN2B protein, human MeSH Browser
- Cyclin-Dependent Kinase Inhibitor p15 MeSH
- Cyclin-Dependent Kinase Inhibitor p16 MeSH
Genome-wide association studies have resulted in the identification of the CDKN2A/2B locus as an important genetic determinant of type 2 diabetes mellitus development. The aim of this study was to investigate the role of this locus in the development of type 2 diabetes mellitus in Czech Slavonic population. Groups of 1,149 type 2 diabetic patients and a group of 2,312 healthy controls, both of Czech origin, were successfully genotyped for the rs10811661 CDK2A/2B tagging polymorphism. The "risky" TT genotype frequencies were almost identical in both examined groups (69.3 % in patients and 68.9 % in controls, P = 0.52; OR [95% CI] = 1.02 [0.87 - 1.19] for TT versus C allele carriers). Similar negative results were obtained when males (P = 0.93) and females (P = 0.23) were analysed separately. We have not confirmed the association between rs10811661 SNP and susceptibility to the type 2 diabetes mellitus in Czech Slavonic population.
