Lack of association between lactotransferrin polymorphism and dental caries
Language English Country Switzerland Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24217007
DOI
10.1159/000351689
PII: 000351689
Knihovny.cz E-resources
- MeSH
- Adenine MeSH
- Arginine genetics MeSH
- Child MeSH
- DMF Index MeSH
- Exons genetics MeSH
- Gene Frequency genetics MeSH
- Genotype MeSH
- Guanine MeSH
- Dental Plaque Index MeSH
- Cohort Studies MeSH
- Lactoferrin genetics MeSH
- Humans MeSH
- Lysine genetics MeSH
- Adolescent MeSH
- Dental Caries Susceptibility genetics MeSH
- Periodontal Index MeSH
- Polymorphism, Genetic genetics MeSH
- Case-Control Studies MeSH
- Dental Calculus classification MeSH
- Dental Caries genetics MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Adenine MeSH
- Arginine MeSH
- Guanine MeSH
- Lactoferrin MeSH
- LTF protein, human MeSH Browser
- Lysine MeSH
OBJECTIVE: Dental caries is a complex, multifactorial disease and one of the most common illnesses worldwide. Its etiology is related to microbial, dietary and host factors. Recent evidence suggests a role of lactotransferrin (LTF) in caries. The purpose of this study was to determine the association between LTF gene polymorphism and dental caries. METHODS: In this case-control study, 637 unrelated children, aged 11-13 years, were enrolled. The subjects were divided into two groups, i.e. caries-free (decayed/missing/filled teeth = 0) and caries-affected children (decayed/missing/filled teeth ≥ 1). The LTF rs1126478 (140A/G in exon 2, Lys/Arg) genotypes were determined by PCR with restriction analysis using the EarI enzyme. RESULTS: Of 637 children, 155 (24.3%) were caries free. There were no statistically significant differences between caries levels and allele or genotype distributions in the total cohort. When the caries-affected group (n = 482) was stratified into low (decayed/missing/filled teeth = 1), moderate (2 ≤ decayed/missing/filled teeth ≤ 3) and high (decayed/missing/filled teeth ≥ 4) caries experience, allele and genotype frequencies were similar among all subgroups. CONCLUSIONS: The LTF 140A/G (exon 2, Lys/Arg) polymorphism was not associated with the susceptibility to or severity of dental caries in the Czech population.
References provided by Crossref.org
Matrix metalloproteinases gene variants and dental caries in Czech children
