Effects of an iodine-restricted food on client-owned cats with hyperthyroidism
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
PubMed
24232246
PubMed Central
PMC11112180
DOI
10.1177/1098612x13512627
PII: 1098612X13512627
Knihovny.cz E-resources
- MeSH
- Animal Nutritional Physiological Phenomena MeSH
- Hyperthyroidism diet therapy etiology veterinary MeSH
- Iodine adverse effects MeSH
- Cats MeSH
- Animal Feed statistics & numerical data MeSH
- Cat Diseases diet therapy etiology MeSH
- Prospective Studies MeSH
- Animals MeSH
- Check Tag
- Cats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Iodine MeSH
The objective of this prospective, multicentre, non-controlled, open-label study was to evaluate the effects of an iodine-restricted food on circulating total thyroxine (TT4) concentrations and clinical parameters in client-owned cats with hyperthyroidism. Two hundred and twenty-five cats were enrolled in the study and adapted to the iodine-restricted food. Data from physical examinations, questionnaires completed by veterinarians and owners, and circulating concentrations of TT4, urea and creatinine were recorded at weeks 0, 4 and 8. The study group included 136 female and 89 male cats (median age 15 years, range 4-21 years). Group 1 (n = 113) had been on previous anti-thyroid medication, while group 2 (n = 112) consisted of newly diagnosed cats. No differences were found between the two groups at any time point. Circulating TT4 concentrations had decreased (P <0.0001) at week 4 and did not change significantly from week 4 to week 8. Circulating TT4 concentration was within the reference range in 56/88 cats at week 4 and in 51/68 cats at week 8. Clinical parameters (vomiting, polyuria, polydipsia, hyperactivity, polyphagia, weight loss, hair coat quality, and quality of life) had improved (P <0.0001) by week 4. Circulating creatinine concentration decreased (P = 0.001) from week 0 to week 4. Side effects associated with feeding the iodine-restricted food were not observed. In conclusion, in client-owned cats with hyperthyroidism an iodine-restricted food is a valuable management option to normalise circulating TT4 concentrations, and improve clinical signs of hyperthyroidism within 4 weeks. This applies to newly diagnosed cats, as well as to previously diagnosed cats receiving anti-thyroid drugs.
See more in PubMed
Holzworth J, Theran P, Carpenter JL, et al.. Hyperthyroidism in the cat: ten cases. J Am Vet Med Assoc 1980; 176: 345–353. PubMed
Peterson ME, Johnson GF, Andrews LK. Spontaneous hyperthyroidism in the cat. In: ACVIM conference, Seattle, WA, USA. Malden: Wiley, 1979, p108.
Peterson M. Hyperthyroidism in cats: what’s causing this epidemic of thyroid disease and can we prevent it? J Feline Med Surg 2012; 14: 804–818. PubMed PMC
Rijnberk A, Kooistra HS. Thyroids. In: Rijnberk A, Kooistra HS. (eds). Clinical endocrinology of dogs and cats. 2nd ed. Hannover: Schlütersche, 2010, pp 73–79.
Peterson ME, Ward CR. Etiopathologic findings of hyperthyroidism in cats. Vet Clin North Am Small Anim Pract 2007; 37: 633–645. PubMed
Kintzer PP. Considerations in the treatment of feline hyperthyroidism. Vet Clin North Am Small Anim Pract 1994; 24: 577–585. PubMed
National Research Council. Minerals. In: National Research Council (ed). Nutrient requirements of dogs and cats. Washington: National Academies Press, 2006, p 181.
Melendez LM, Yamka SD, Forrester PA, et al.. Titration of dietary iodine for reducing serum thyroxine concentrations in newly diagnosed hyperthyroid cats. ACVIM Forum abstracts; 2011 June 15–18; Denver, USA. Malden: Wiley, abstract no. EN-16, p 683.
Melendez LD, Yamka RM, Burris PA. Titration of dietary iodine for maintaining normal serum thyroxine concentrations in hyperthyroid cats. ACVIM Forum abstracts; 2011 June 15–18; Denver, USA Malden: Wiley, abstract no. EN-17. Malden: Wiley, p 683.
Hand MS, Thatcher CD, Remillard RL, et al.. Small animal clinical nutrition. 5th ed. Topeka: Mark Morris Institute, 2010, pp 5–7.
LaFlamme DP, Kealy RD, Schmidt DA. Estimation of body fat by body condition score. Twelfth annual veterinary medical forum; 1994; ACVIM, San Francisco, USA. Malden: Wiley, p 985.
Burkholder WJ. Body composition of dogs determined by carcass composition analysis, deuterium oxide dilution, subjective and objective morphometry and bioelectrical impedance. PhD dissertation, Virginia Poly Technic Institute and State University, USA, 1994.
Syme HM. Cardiovascular and renal manifestations of hyperthyroidism. Vet Clin North Am Small Anim Pract 2007; 37: 723–743. PubMed
Marino CL, Cober RE, Iazbik MC, et al.. White-coat effect on systemic blood pressure in retired racing Greyhounds. J Vet Intern Med 2011; 25: 861–865. PubMed
Boag AK, Neiger R, Slater L, et al.. Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine. Vet Rec 2007; 161: 711–715. PubMed
Scott-Moncrieff JC. Thyroid disorders in the geriatric veterinary patient. Vet Clin North Am Small Anim Pract 2012; 42: 707–725. PubMed
Fazio S, Palmieri EA, Lombardi G, et al.. Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res 2004; 224: 879–886. PubMed
Butani L, Polinsky MS, Kaiser BA, et al.. Dietary protein intake significantly affects the serum creatinine concentration. Kidney Int 2002; 61: 1907. PubMed
Wedekind KJ, Blumer ME, Huntington CE, et al.. The feline iodine requirement is lower than the 2006 NRC recommended allowance. J Anim Physiol Anim Nutr (Berl) 2010; 94: 527–539. PubMed
