Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24291610
DOI
10.1016/j.mce.2013.11.013
PII: S0303-7207(13)00506-6
Knihovny.cz E-resources
- Keywords
- Adipose tissue, Laparoscopic sleeve gastrectomy, Obesity, Peripheral monocytes,
- MeSH
- Chemokines, CC genetics metabolism MeSH
- Adult MeSH
- Gene Expression * MeSH
- Gastrectomy methods MeSH
- Weight Loss MeSH
- Interleukin-10 genetics metabolism MeSH
- Interleukin-18 genetics metabolism MeSH
- Laparoscopy MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger genetics metabolism MeSH
- Monocytes metabolism pathology MeSH
- Obesity genetics metabolism pathology surgery MeSH
- Organ Specificity MeSH
- Subcutaneous Fat metabolism pathology MeSH
- Receptors, CCR genetics metabolism MeSH
- Gene Expression Profiling MeSH
- Toll-Like Receptor 2 genetics metabolism MeSH
- Toll-Like Receptor 4 genetics metabolism MeSH
- Inflammation genetics metabolism pathology surgery MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chemokines, CC MeSH
- IL10 protein, human MeSH Browser
- Interleukin-10 MeSH
- Interleukin-18 MeSH
- RNA, Messenger MeSH
- Receptors, CCR MeSH
- TLR2 protein, human MeSH Browser
- TLR4 protein, human MeSH Browser
- Toll-Like Receptor 2 MeSH
- Toll-Like Receptor 4 MeSH
Low-grade inflammation links obesity, insulin resistance, and cardiovascular diseases. We investigated the effects of laparoscopic sleeve gastrectomy (LSG) on expression profile of genes involved in inflammatory pathways in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM). At baseline, obese group had significantly increased mRNA expression of proinflammatory chemokines (CCL-3, -17, -22), chemokine receptor CCR1 and cytokines (IL-10, IL-18) in SCAT and chemokine and other proinflammatory receptors (CCR-1, -2, -3, TLR-2, -4) in PM relative to control group. LSG decreased body weight, improved metabolic profile and reduced mRNA expression of up-regulated chemokine receptors, chemokines and cytokines in SCAT. In contrast, expression profiles in PM were largely unaffected by LSG. We conclude that LSG improved proinflammatory profile in subcutaneous fat but not in peripheral monocytes. The sustained proinflammatory and chemotactic profile in PM even 2 years after LSG may contribute to partial persistence of metabolic complications in obese patients after metabolic surgery.
References provided by Crossref.org
