Lower omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24329700
DOI
10.33549/physiolres.932626
PII: 932626
Knihovny.cz E-resources
- MeSH
- Biomarkers blood MeSH
- Dietary Fats, Unsaturated blood pharmacokinetics MeSH
- Hypertension blood complications MeSH
- Blood Pressure MeSH
- Rats MeSH
- Fatty Acids, Omega-3 blood MeSH
- Rats, Inbred SHR MeSH
- Rats, Wistar MeSH
- Prognosis MeSH
- Reproducibility of Results MeSH
- Risk Factors MeSH
- Sensitivity and Specificity MeSH
- Arrhythmias, Cardiac blood etiology MeSH
- Heart Rate MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Dietary Fats, Unsaturated MeSH
- Fatty Acids, Omega-3 MeSH
Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of omega-3 and omega-6 PUFA as well as to determine omega-3 index, a risk factor for sudden cardiac death, in aged SHR and the effect of omega-3 PUFA intake. Male and female 12-month-old SHR and age-matched Wistar rats fed with omega-3 PUFA (200 mg/kg BW/day/2 month) were compared with untreated rats. Composition of omega-3 PUFA: alpha linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as omega-6 PUFA: linoleic acid and arachidonic acid was analyzed by gas chromatography. Results showed sex- and strain-related differences of basal omega-3 and omega-6 PUFA levels in plasma and RBC as well as in response to omega-3 PUFA intake. Comparing to Wistar rats omega-3 index, expressed as a percentage of EPA+DHA of total fatty acids, was lower in SHR and it increased due to consumption of omega-3 PUFA. Findings support our hypothesis that lower omega-3 index may be also a marker of increased propensity of the hypertensive rat heart to malignant arrhythmias.
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