Low contrast volume run-off CT angiography with optimized scan time based on double-level test bolus technique--feasibility study
Language English Country Ireland Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
24380637
DOI
10.1016/j.ejrad.2013.12.004
PII: S0720-048X(13)00645-1
Knihovny.cz E-resources
- Keywords
- CT angiography, Contrast medium, Peripheral vascular disease, Run-off, Test bolus,
- MeSH
- Algorithms * MeSH
- Angiography methods MeSH
- Injections, Intra-Arterial MeSH
- Image Interpretation, Computer-Assisted methods MeSH
- Contrast Media administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Peripheral Arterial Disease diagnostic imaging MeSH
- Tomography, X-Ray Computed methods MeSH
- Reproducibility of Results MeSH
- Sensitivity and Specificity MeSH
- Feasibility Studies MeSH
- Image Enhancement methods MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Contrast Media MeSH
PURPOSE: To verify the technical feasibility of low contrast volume (40 mL) run-off CT angiography (run-off CTA) with the individual scan time optimization based on double-level test bolus technique. MATERIALS AND METHODS: A prospective study of 92 consecutive patients who underwent run-off CTA performed with 40 mL of contrast medium (injection rate of 6 mL/s) and optimized scan times on a second generation of dual-source CT. Individual optimized scan times were calculated from aortopopliteal transit times obtained on the basis of double-level test bolus technique--the single injection of 10 mL test bolus and dynamic acquisitions in two levels (abdominal aorta and popliteal arteries). Intraluminal attenuation (HU) was measured in 6 levels (aorta, iliac, femoral and popliteal arteries, middle and distal lower-legs) and subjective quality (3-point score) was assessed. Relations of image quality, test bolus parameters and arterial circulation involvement were analyzed. RESULTS: High mean attenuation (HU) values (468; 437; 442; 440; 342; 274) and quality score in all monitored levels was achieved. In 91 patients (0.99) the sufficient diagnostic quality (score 1-2) in aorta, iliac and femoral arteries was determined. A total of 6 patients (0.07) were not evaluable in distal lower-legs. Only the weak indirect correlation of image quality and test-bolus parameters was proved in iliac, femoral and popliteal levels (r values: -0.263, -0.298 and -0.254). The statistically significant difference of the test-bolus parameters and image quality was proved in patients with occlusive and aneurysmal disease. CONCLUSION: We proved the technical feasibility and sufficient quality of run-off CTA with low volume of contrast medium and optimized scan time according to aortopopliteal transit time calculated from double-level test bolus.
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