What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
24384232
DOI
10.1016/j.envint.2013.12.009
PII: S0160-4120(13)00298-5
Knihovny.cz E-zdroje
- Klíčová slova
- Environmental risk assessment, Estrogen, In vitro assay, Threshold, Waste water treatment plant,
- MeSH
- biotest MeSH
- chemické látky znečišťující vodu analýza MeSH
- estreny analýza MeSH
- estrogeny analýza MeSH
- kvalita vody normy MeSH
- lidé MeSH
- monitorování životního prostředí MeSH
- odpadní voda chemie MeSH
- řeky chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- chemické látky znečišťující vodu MeSH
- estreny MeSH
- estrogeny MeSH
- odpadní voda MeSH
In vitro assays are broadly used tools to evaluate the estrogenic activity in Waste Water Treatment Plant (WWTP) effluents and their receiving rivers. Since potencies of individual estrogens to induce in vitro and in vivo responses can differ it is not possible to directly evaluate risks based on in vitro measures of estrogenic activity. Estrone, 17beta-estradiol, 17alfa-ethinylestradiol and to some extent, estriol have been shown to be responsible for the majority of in vitro estrogenic activity of municipal WWTP effluents. Therefore, in the present study safe concentrations of Estrogenic Equivalents (EEQs-SSE) in municipal WWTP effluents were derived based on simplified assumption that the steroid estrogens are responsible for all estrogenicity determined with particular in vitro assays. EEQs-SSEs were derived using the bioassay and testing protocol-specific in vitro potencies of steroid estrogens, in vivo predicted no effect concentration (PNECs) of these compounds, and their relative contributions to the overall estrogenicity detected in municipal WWTP effluents. EEQs-SSEs for 15 individual bioassays varied from 0.1 to 0.4ng EEQ/L. The EEQs-SSEs are supposed to be increased by use of location-specific dilution factors of WWTP effluents entering receiving rivers. They are applicable to municipal wastewater and rivers close to their discharges, but not to industrial waste waters.
Citace poskytuje Crossref.org
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