D-dimer levels and 90-day outcome in patients with acute pulmonary embolism with or without cancer
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24438941
DOI
10.1016/j.thromres.2013.12.044
PII: S0049-3848(14)00008-5
Knihovny.cz E-zdroje
- MeSH
- antikoagulancia terapeutické užití MeSH
- fibrin-fibrinogen - produkty degradace analýza metabolismus MeSH
- lidé MeSH
- nádory krev MeSH
- plicní embolie krev MeSH
- prognóza MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antikoagulancia MeSH
- fibrin fragment D MeSH Prohlížeč
- fibrin-fibrinogen - produkty degradace MeSH
BACKGROUND: The prognostic value of D-dimer testing in patients with acute pulmonary embolism (PE) has not been thoroughly studied. METHODS: We used the RIETE Registry data to assess the 90-day prognostic value of increased IL Test D-dimer levels at baseline in patients with PE, according to the presence or absence of cancer. RESULTS: As of May 2013, 3,283 patients with acute PE underwent D-dimer testing using IL Test D-dimer. Among 2,588 patients without cancer, those with D-dimer levels in the highest quartile had a higher rate of fatal PE (2.6% vs. 0.9%; p=0.002), fatal bleeding (1.1% vs. 0.3%; p=0.017) and all-cause death (9.1% vs. 4.4%; p<0.001) at 90 days compared with those with levels in the lowest quartiles. Among 695 patients with cancer, those with levels in the highest quartile had a similar rate of fatal PE or fatal bleeding but higher mortality (35% vs. 24%; p<0.01). On multivariate analysis, non-cancer patients with D-dimer levels in the highest quartile had an increased risk for fatal PE (odds ratio [OR]: 3.3; 95% CI: 1.6-6.6), fatal bleeding (OR: 4.3; 95% CI: 1.4-13.7) and all-cause death (OR: 2.1; 95% CI: 1.4-3.1) compared with patients with levels in the lowest quartiles. CONCLUSIONS: Non-cancer patients with acute PE and IL Test D-dimer levels in the highest quartile had an independently higher risk for fatal PE, fatal bleeding and all-cause death at 90 days than those with levels in the lowest quartiles. In patients with cancer, D-dimer levels failed to predict fatal PE or fatal bleeding.
Department of Haematology Hospital Lluís Alcanyís Xàtiva Spain
Department of Internal Medicine Hospital Universitari Germans Trias i Pujol Badalona Barcelona Spain
Department of Internal Medicine Hospital Vinalopó Salud Elche Alicante Spain
Department of Pneumonology Hospital de Txagorritxu Alava Vitoria Spain
Internal Medicine Thrombosis Center Ospedale Galliera Genoa Italy
Vascular Medicine Ospedale Castel Franco TV Castelfranco Veneto Italy
Citace poskytuje Crossref.org