The role of connexin40 in developing atrial conduction
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24486905
DOI
10.1016/j.febslet.2014.01.032
PII: S0014-5793(14)00061-1
Knihovny.cz E-resources
- Keywords
- Arrhythmogenesis, Heart development, Mouse embryo, Optical mapping, Sinoatrial node,
- MeSH
- Fetal Heart metabolism physiology MeSH
- Connexins genetics metabolism MeSH
- Mice MeSH
- Sinoatrial Node embryology metabolism physiology MeSH
- Gap Junction alpha-5 Protein MeSH
- Atrial Appendage embryology metabolism physiology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Connexins MeSH
Connexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria.
References provided by Crossref.org
Erbb2 is required for cardiac atrial electrical activity during development
