The role of connexin40 in developing atrial conduction
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24486905
DOI
10.1016/j.febslet.2014.01.032
PII: S0014-5793(14)00061-1
Knihovny.cz E-zdroje
- Klíčová slova
- Arrhythmogenesis, Heart development, Mouse embryo, Optical mapping, Sinoatrial node,
- MeSH
- fetální srdce metabolismus fyziologie MeSH
- konexiny genetika metabolismus MeSH
- myši MeSH
- nodus sinuatrialis embryologie metabolismus fyziologie MeSH
- protein alfa 5 mezerového spoje MeSH
- síňové ouško embryologie metabolismus fyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- konexiny MeSH
Connexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria.
Citace poskytuje Crossref.org
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