CD14+CD16+ and CD14+CD163+ monocyte subpopulations in kidney allograft transplantation
Language English Country England, Great Britain Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24499053
PubMed Central
PMC3918100
DOI
10.1186/1471-2172-15-4
PII: 1471-2172-15-4
Knihovny.cz E-resources
- MeSH
- Lipopolysaccharide Receptors metabolism MeSH
- CD36 Antigens metabolism MeSH
- Antigens, Differentiation, B-Lymphocyte metabolism MeSH
- Antigens, Differentiation, Myelomonocytic metabolism MeSH
- Antigens, CD metabolism MeSH
- Adult MeSH
- Phenotype MeSH
- Histocompatibility Antigens Class II metabolism MeSH
- Transplantation, Homologous MeSH
- Immunophenotyping MeSH
- Immunosuppressive Agents pharmacology MeSH
- Middle Aged MeSH
- Humans MeSH
- Monocytes drug effects immunology metabolism MeSH
- Graft Survival immunology MeSH
- Flow Cytometry MeSH
- Receptors, Cell Surface metabolism MeSH
- Receptors, IgG metabolism MeSH
- Graft Rejection immunology MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Kidney Transplantation * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Lipopolysaccharide Receptors MeSH
- CD36 Antigens MeSH
- Antigens, Differentiation, B-Lymphocyte MeSH
- Antigens, Differentiation, Myelomonocytic MeSH
- Antigens, CD MeSH
- CD163 Antigen MeSH
- Histocompatibility Antigens Class II MeSH
- Immunosuppressive Agents MeSH
- invariant chain MeSH Browser
- Receptors, Cell Surface MeSH
- Receptors, IgG MeSH
BACKGROUND: Monocytes represent a heterogeneous population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes. The aim of our study was to evaluate the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. RESULTS: The phenotype was evaluated by flow cytometry in defined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjusted to basal values in two months. The proportions of CD14+CD163+ monocytes were transiently upregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, the expansion of CD14+CD163+ monocytes was delayed but their upregulation lasted longer. In vitro data showed the direct effect of ATG and methylprednisolone on expression of CD16 and CD163 molecules while basiliximab did not affect the phenotype of cultured monocytes. CONCLUSIONS: We assume from our data that kidney allograft transplantation is associated with modulation of monocyte subpopulations (CD14+CD16+ and CD14+CD163+) partially affected by an immunosuppressive regime used.
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