Role of calprotectin in cardiometabolic diseases
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24560084
DOI
10.1016/j.cytogfr.2014.01.005
PII: S1359-6101(14)00006-9
Knihovny.cz E-resources
- Keywords
- Calprotectin, Cardiovascular diseases, Metabolic diseases, Myocardial infarction, Obesity,
- MeSH
- Acute Coronary Syndrome physiopathology MeSH
- Atherosclerosis etiology MeSH
- Biomarkers MeSH
- Inflammatory Bowel Diseases physiopathology MeSH
- Cardiovascular Diseases etiology physiopathology MeSH
- Leukocyte L1 Antigen Complex physiology MeSH
- Humans MeSH
- Coronary Artery Disease physiopathology MeSH
- Prognosis MeSH
- Risk MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
- Leukocyte L1 Antigen Complex MeSH
Calprotectin represents an interesting peptide known to be involved in the pathophysiology of various inflammatory processes. Being secreted from activated neutrophils and monocytes under various conditions, it can also be found in the extracellular fluids and serve as a biomarker of ongoing inflammation, which property is currently used in the monitoring of inflammatory bowel diseases. Recent studies, however, suggest that calprotectin could serve as an important prognostic factor for cardiovascular and cardiometabolic diseases, since these are occurring on the basis of low-grade chronic inflammation. We assume that calprotectin may represent a useful marker in predicting the course of atherosclerotic process, coronary artery disease and acute coronary syndromes. Our review is focused on the importance of calprotectin in the diagnosis and prognostic stratification in the field of cardiometabolic risk.
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