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Article

PubMed

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Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with inflammatory bowel disease--an ECCO-EpiCom study

Journal of Crohn's & colitis. 2014 Sep ; 8 (9) : 1030-42. [epub] 20140221

J Crohns Colitis
ISSN 1876-4479 | 1873-9946
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid24560877

PubMed 24560877
DOI 10.1016/j.crohns.2014.01.028
PII: S1873-9946(14)00047-6
Knihovny.cz E-resources

Keywords
Disease course, Epidemiology;, Inception cohort;, Quality of life;,
MeSH
Digestive System Surgical Procedures methods MeSH
Adult MeSH
Inflammatory Bowel Diseases epidemiology psychology therapy MeSH
Quality of Life * MeSH
Middle Aged MeSH
Humans MeSH
Disease Management * MeSH
Adolescent MeSH
Young Adult MeSH
Morbidity trends MeSH
Follow-Up Studies MeSH
Prognosis MeSH
Prospective Studies MeSH
Surveys and Questionnaires MeSH
Aged, 80 and over MeSH
Aged MeSH
Population Surveillance * MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Adolescent MeSH
Young Adult MeSH
Male MeSH
Aged, 80 and over MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Research Support, Non-U.S. Gov't MeSH
Geographicals
Europe epidemiology MeSH

BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe. METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up. RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population. CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

1st Department of Medicine Semmelweis University Budapest Hungary

1st Division of Internal Medicine and Division of Gastroenterology Medical School University of Ioannina Ioannina Greece

Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania

Department of Gastroenterology Adelaide and Meath Hospital TCD Dublin Ireland

Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere Finland

Department of Gastroenterology and Hepatology Soroka Medical Center and Ben Gurion University of the Negev Beer Sheva Israel; Department of Gastroenterology and Hepatology Ben Gurion University of the Negev Beer Sheva Israel

Department of Gastroenterology Hospital São João Porto Portugal; Institute of Pharmacology and Therapeutics Faculty of Medicine University of Porto Porto Portugal; IBMC Institute for Molecular and Cell Biology University of Porto Porto Portugal

Department of Gastroenterology Moscow Regional Research Clinical Institute Moscow Russian Federation

Department of Gastroenterology State University of Medicine and Pharmacy of the Republic of Moldova Chisinau Republic of Moldova

Department of Internal Medicine Section of Gastroenterology and Hepatology The National University Hospital Reykjavik Iceland

Department of Medical Gastroenterology Gentofte Hospital Copenhagen Denmark

Department of Medical Gastroenterology Odense University Hospital Odense Denmark