Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24632008
DOI
10.1016/j.bbr.2014.03.001
PII: S0166-4328(14)00143-0
Knihovny.cz E-resources
- Keywords
- Acquisition, Consolidation, Muscarinic receptors, Passive avoidance, Retrieval, Water maze,
- MeSH
- Analysis of Variance MeSH
- Muscarinic Antagonists chemistry toxicity MeSH
- Maze Learning drug effects MeSH
- Time Factors MeSH
- Quinuclidinyl Benzilate chemistry toxicity MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Statistics, Nonparametric MeSH
- Motor Activity drug effects MeSH
- Learning Disabilities chemically induced MeSH
- Rats, Wistar MeSH
- Mental Recall drug effects MeSH
- Avoidance Learning drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Muscarinic Antagonists MeSH
- Quinuclidinyl Benzilate MeSH
3-Quinuclidinyl benzilate (QNB) represents a non-selective, competitive antagonist of cholinergic receptors, which has been previously used to generate cognitive deficits in animal models of neurodegenerative disorders. The aim of this study was evaluation of QNB potency for creation of cognitive impairment during the acquisition, consolidation and retrieval stages of learning and memory in rats. Male Wistar rats were subjected to a water maze task with hidden platform and a step-through passive avoidance task. The water maze test was carried out in two separate experiments focused on spatial learning (acquisition test) and long-term spatial memory (retrieval test). QNB doses (0.5, 1.0, 2.0 and 5.0 mg kg(-1)) were administered to rats intraperitoneally before training sessions (acquisition test) or before probe trial (retrieval test). A QNB dose of 2.0 mg kg(-1) was administered to rats in the passive avoidance task before training (acquisition test), immediately post-training (consolidation test) or 24h pre-retention (retrieval test). QNB significantly impaired the acquisition in the water maze at doses 0.5-5.0 mg kg(-1) as well as the acquisition of passive avoidance task. In contrast, consolidation and retrieval were not affected by QNB, indicating that QNB specifically affects the stage of acquisition.
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