Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24636338
DOI
10.1016/j.leukres.2014.01.012
PII: S0145-2126(14)00030-7
Knihovny.cz E-resources
- Keywords
- Chromothripsis, Complex chromosomal aberrations, Deletion 5q, Genome instability, Myelodysplastic syndromes,
- MeSH
- Chromosome Deletion * MeSH
- Adult MeSH
- Karyotype MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 5 * MeSH
- Myelodysplastic Syndromes genetics mortality MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Comparative Genomic Hybridization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).
Institute of Hematology and Blood Transfusion Prague Czech Republic
Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic
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