Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24636338
DOI
10.1016/j.leukres.2014.01.012
PII: S0145-2126(14)00030-7
Knihovny.cz E-zdroje
- Klíčová slova
- Chromothripsis, Complex chromosomal aberrations, Deletion 5q, Genome instability, Myelodysplastic syndromes,
- MeSH
- chromozomální delece * MeSH
- dospělí MeSH
- karyotyp MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 5 * MeSH
- myelodysplastické syndromy genetika mortalita MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srovnávací genomová hybridizace MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).
Institute of Hematology and Blood Transfusion Prague Czech Republic
Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic
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