Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24769247
DOI
10.1016/j.steroids.2014.04.007
PII: S0039-128X(14)00078-6
Knihovny.cz E-resources
- Keywords
- Anticancer activity, Brassinosteroids, Molecular docking, Organic synthesis, Plant bioassays, Receptor kinase BRI1,
- MeSH
- Brassinosteroids administration & dosage chemical synthesis MeSH
- Cholestanols administration & dosage chemical synthesis MeSH
- Cytotoxins administration & dosage chemical synthesis MeSH
- Humans MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Cell Proliferation drug effects MeSH
- Steroids, Heterocyclic administration & dosage MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- brassinolide MeSH Browser
- Brassinosteroids MeSH
- Cholestanols MeSH
- Cytotoxins MeSH
- Steroids, Heterocyclic MeSH
Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.
References provided by Crossref.org
Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups
Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain
